Methyl benzoate has a pleasant smell, strongly reminiscent of the fruit of the feijoa tree, and it is used in perfumery. For excipients see section 6.1 Avoid prolonged contact with skin and clothing. a Weigh 2.0 g of methyl benzoate into a dry 50 cm3 conical flask. P211: difficulty in urinating (dribbling) jerking movements. However the 3-position is less deactivated towards nitration than the other positions owing to the relative stability of the different intermediates. Combustible. . : 93-58-3 1.2 Relevant identifi ed uses of the substance or mixture and uses advised against . Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Pharmaceutical particulars; 6.1 List of excipients; 6.2 Incompatibilities; 6.3 Shelf life; 6.4 Special precautions for storage; 6.5 Nature and contents of container; 6.6 Special precautions for disposal and other handling; 7. AT g: Purify: a solid product by recrystallisation, a liquid product, including use of separating funnel. 5 0 obj PB85141216. Tallest Building In New York 2022, The nitration of methyl benzoate is an example of electrophilic substitution. It does not represent any guarantee of the properties of the product. SAFETY DATA SHEET. No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20C. Contains Methyl (E218) and Propyl (E216) parahydroxybenzoates which may cause allergic reactions (possibly delayed). endobj PRODUCT AND COMPANY IDENTIFICATION 1.1 Product identifiers Product name : Methyl benzoate Product Number : M29908 Brand : Aldrich CAS-No. l Record the melting point of your sample of methyl 3-nitrobenzoate. 0000003105 00000 n Yu7&*4}"/u :Sky6) Methyl benzoate is more reactive than methyl propanoate because the phenyl group withdraws electrons from the carbonyl carbon by an inductive effect, which increases the electrophilicity of the carbonyl carbon. swallowed. << g Allow the ice to melt and filter under suction. <> stream Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index. Geriatric Use Methyl benzoate | C6H5COOCH3 or C8H8O2 | CID 7150 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Koc values for the Podzol, Alfisol and sediment were 178, 103, and 95, respectively(1). Gabapentin is a gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. 0000017719 00000 n The safety of Methyl Benzoate, Ethyl Benzoate, Propyl Benzoate, Butyl Benzoate, Isopropyl Benzoate and Isobutyl Benzoate has been assessed by the Cosmetic Ingredient Review (CIR) Expert Panel. ]2}S6!suLfn7#7?6C&NVva$x$f{_L`n63|X4CvF2:k'8|i8C_Nu?|~s_8U;$Cm_>x^O9{7|* (n. Storage class (TRGS 510): Combustible liquids. METHYL BENZOATE is an ester. 4.10.5 prepare methyl-3-nitrobenzoate from methyl benzoate to illustrate nitration of the benzene ring. Clorius; Essence of niobe; Benzoic acid,methyl ester. Skin: The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Illustrative of its ability to undergo electrophilic substitution, methyl benzoate undergoes acidcatalysed nitration with nitric acid to give methyl 3-nitrobenzoate. INDICATIONS. Oxidising gases (section 2.4) 1: P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely. ETHYL BENZOATE FOR SYNTHESIS Safety Data Sheet www.lobachemie.com 01/06/2016 3/8 5.3. : AC126340000; AC126340025; AC126340100; AC126340250; AC126345000 . Re@#@Id J3}&cRBep(5D L# L]b`W)>M~C\3P b#chMs1 BrSDXpS@0G'Q#eE!l&. Solid methyl 3-nitrobenzoate will form. 0000001694 00000 n View 6933-47-7/Methyl 4-amino-2-methylbenzoateinformation and document regarding Methyl 4-amino-2-methylbenzoate, including NMR, HPLC, LC-MS, UPLC & more. Always follow good hygienic work practices. Pharmaceutical particulars; 6.1 List of excipients; 6.2 Incompatibilities; 6.3 Shelf life; 6.4 Special precautions for storage; 6.5 Nature and contents of container; 6.6 Special precautions for disposal and other handling; 7. ; Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations. stream After completion stir for 5 more min. stream Preparation of methyl 3-nitrobenzoate. f Methyl Benzoate may cause a skin allergy and an asthma-like allergy. Stable. Glucose 1100mg/5ml. It is functionally related to a gamma-aminobutyric acid. Mildly toxic by skin contact. Esters react with acids to liberate heat along with alcohols and acids. When heated to decomposition it emits Methyl benzoate can be isolated from the freshwater fern Salvinia molesta. Methyl benzoate CAS-No. 0000002359 00000 n ADAL1200724: Brand: SynHet: Chemical formula: C21H26N2O4: Room temp. Do NOT induce vomiting. Follow this link for more information about how preservatives protect cosmetics and personal care products. Benzoic acid, methyl ester; Oil of niobe. dynamic viscosity (in mPa s) = 1.94. Handle in accordance with good industrial hygiene and safety practice. Use ideal body weight to calculate dose. 2 0 obj Methyl benzoate is an organic compound. Propyl hydroxybenzoate (E216) 4mg/5ml. gZR0,Ti6,`_9 IE.H JAL Precautions for safe handling : Avoid contact with skin, eyes and clothing. Product name : Methyl-p-Hydroxy Benzoate Sodium Salt CAS-No. %PDF-1.4 The vapour is heavier than air.METHYL BENZOATE is an ester. It also finds use as a solvent and as a pesticide used to attract The principal food safety incident in Taiwan was over the use of the plasticizer DEHP to replace palm oil in food and drinks as a clouding agent. SAFETY DATA SHEET Version 5.2 Revision Date 04/02/2015 Print Date 12/20/2016 1. Methyl benzoate Uses advised against Food, drug, pesticide or biocidal product use. Rest. SODIUM BORATE, DECAHYDRATE By Molarity 0.1 M Sodium Borate Environmental Health and Safety 416.978.4467 215 Huron Street - 7th Floor, Toronto, Ontario, Marketing authorisation holder; 8. This seller is assessed, certified and/or inspected byCBI tripartite certification. Interestingly, methyl salicylate and methyl benzoate are both produced by methylation of salicylic and benzoic acids, respectively, controlled by the same gene in A. thaliana. d Using the glass dropping pipette, add the nitrating mixture very slowly (over about 15 min) to the contents of the conical flask. Methyl benzoate also has a reported log Koc value of 2.10 (Koc = 126)(2). Caution! Methyl benzoate is manufactured by heating benzoic acid and dimethyl sulfate to high temperature, or by exchange between ethyl benzoate and methanol in KOH solution. Therefore the crude material can be purified by recrystallization from a water/ethanol mixture. endobj Box 219, Batavia, IL 60510 (800) 452-1261 Chemtrec Emergency Phone Number: (800) 424-9994 SAFETY DATA SHEET Revision Date 24-Dec-2021 Revision Number 6 1. Diazomethane is the chemical compound CH 2 N 2, discovered by German chemist Hans von Pechmann in 1894. Liquid of moderate to poor tenacity. 1 0 obj Moderately toxic by Stir the crushed ice throughout. Methyl 3-nitrobenzoate is insoluble in water but soluble in hot ethanol. Excipients with known effect: Sorbitol Solution 70% (E420) 0.8mg/5ml. Methyl benzoate reacts with strong oxidizing agents and strong bases and hydrolyzes slowly in contact with water. Ethyl hydroxybenzoate (E214) 5mg/5ml. 5!GJ3q"R5T0523"S@/% 2 mh:tR@0244F`PYb_MPz V$( q*87%8pYXTDYBZ LL !utIq AM~$*hSUyTT#maw5q8W7#7\ AQC%Fn4n4|9wA V:i>{&7}[wAl^6$bX)}|DZ)Q{Pmp?m`@ P376: Stop leak if safe to do so. 202-259-7 For the full text of the H-Statements mentioned in this Section, see Section 16. . IDENTIFICATION phenyl methyl benzoate BENZYL PHENYL FORMATE BENZYL BENZOATE 120-51-4 100 4. xref 6.1 Personal precautions . Methyl benzoate | C6H5COOCH3 - PubChem Apologies, we are having some trouble retrieving data from our servers. Do you expect ortho-, meta-, or para-nitration? Obtain medical attention. <> M205-500 Inhalation: 5. (We`ll never share your email address with a third-party.). It is naturally occurring in guava, mango, and kiwifruit. This section provides a listing of alternate names for this chemical, Esters react with acids to liberate heat along with alcohols and acids. Product name : Methyl benzoate Product Number : M29908 Brand : Aldrich CAS-No. It is an ester with the chemical formula C 6 H 5 CO 2 CH 3. Blister formation, crusting, itching, oozing, reddening, or scaling of skin. Sigma-Aldrich Co., shall not be held liable for . An estimated BCF of 12 was calculated in fish for methyl benzoate(SRC), using a log Kow of 2.12(1) and a regression-derived equation(2). Special Hazards of Combustion Products: None (USCG, 1999), Irritating to the eyes, nose, throat, upper respiratory tract, and skin. a Weigh 2.0 g of methyl benzoate into a dry 50 cm 3 conical flask. Methyl benzoate; (Benzoic acid, methyl ester) (93-58-3). << 26 34 The term "iso" in the name means that the carbon chain of the alcohol is branched. Company Identification: Fisher Scientific 1 Reagent Lane Fair Lawn, NJ 07410 For information, call: 201-796-7100 Emergency Number: 201-796-7100 For CHEMTREC assistance, call: 800-424-9300 "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#|M~0B"ty'{{E0k"^8$p(?k({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>uN|)IFovp,D>_2@f`3&.=p?cy=kR=02X=}`!}'sfo`PR?|)N5 >_`faQ '36h;0(N:Pc\iA $&:r}t[gk~]q}w6OqL;,g4|Ra^NLxu3! Office of Response and Restoration, The European Union lists salts and esters of benzoic acid (including Methyl Benzoate, Ethyl Benzoate, Propyl Benzoate, Butyl Benzoate, Isopropyl Benzoate and Isobutyl Benzoate) as preservatives that may be safety used in cosmetics at concentrations up to 0.5% (See Annex IV). startxref Members are provided with comprehensive ways to promote their products. Do not discharge to sewer systems. Esters react with acids to liberate heat along with alcohols and acids. <> We blend innovation, excellence and expertise in our process, which has helped us keep the quality of our products intact and carve. Rinse mouth. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. 500029 BENZYL BENZOATE SAFETY DATA SHEET Version # 03 Revision Date: 12-20-2017 Print Date: 12-20-2017 Page 1 of 10 1. Approved respirator, chemical safety goggles, chemical-resistant gloves. knowledge and is applicable to the product with regard to appropriate safety precautions. It is a colorless liquid that is poorly soluble in water, but miscible with organic solvents. The methyl 3-nitrobenzoate will melt at this temperature but you will be able to see an oily substance within the water. Take precautionary Warning. It is useful for the prevention of tonic-clonic seizures (also known as grand mal seizures) and focal seizures, but not absence seizures. . Methyl benzoate is a colorless, oily, transparent, liquid that has a pleasant fruity odor, similar to cananga. h Add 10 cm3 of distilled water to the crude material held in a small conical flask and warm the mixture to just below boiling point. Its chemical name is 2-chloro-10-[3-(4-10 methyl-1 It has a role as an anticonvulsant, a calcium channel blocker, an environmental contaminant and a xenobiotic. DOSAGE AND ADMINISTRATION. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. If it pass ECHEMI audit , supplier can get logo of certified business license. Avoid contact with skin and eyes. Methyl Benzoate, Ethyl Benzoate, Propyl Benzoate, Butyl Benzoate, Isopropyl Benzoate and Isobutyl Benzoate may be used in cosmetics and personal care products as fragrance ingredients and preservatives. Metronidazole Benzoate Ph Eur 320mg/5ml. The most commonly reported adverse reaction during treatment is pruritus. Precautions for Scalp and Hair Treatment: Avoid contact with the eyes. <> 0000004524 00000 n We provide Methyl3-(aminomethyl)benzoate safety data sheet view and download for free at Echemi.com. Perform CPR as necessary. Box 219, Batavia, IL 60510 (800) 452-1261 Chemtrec Emergency Phone Number: (800) 424-9994 SAFETY DATA SHEET Revision Date 24-Dec-2021 Revision Number 6 1. Based on the information reviewed, the CIR Expert Panel concluded that Methyl Benzoate, Ethyl Benzoate, Propyl Benzoate, Butyl Benzoate, Isopropyl Benzoate and Isobutyl Benzoate were safe as used in cosmetic products. Thermacell Radius Zone Mosquito Repellent, Drug Interaction Studies and PRECAUTIONS.) Copyright 2022 ChemicalBook. Cool this mixture by partially immersing the flask in an ice-water bath. Pictograms. f Methyl Benzoate can affect you when inhaled and may be absorbed through the skin. 1979. The CIR Expert Panel reviewed safety data on Methyl Benzoate, Ethyl Benzoate, Propyl Benzoate, Butyl Benzoate, Isopropyl Benzoate and Isobutyl Benzoate as well as data on the components of these ingredients including benzoic acid, methyl alcohol, ethyl alcohol, propyl alcohol, butyl alcohol and isopropyl alcohol. Methyl benzoate is a volatile aromatic ester compound widely used in perfumery industries. Methyl Benzoate and Isobutyl Benzoate may also be used as solvents. - No smoking. Dissolve or mix the material Look through Methyl3-(aminomethyl)benzoate MSDS details show. A crystalline solid or a solid dissolved in a liquid. P376: Stop leak if safe to do so. Identification Product Name Methyl benzoate Cat No. Show this safety data sheet to the doctor in attendance. Safety assessment. NO open flames. Your Trusted Stop To Buy The Best Mint Products. Sucrose 625mg/5ml. Cosmeticsinfo.org. Remove the cold bath and let the mixture stand at room temperature for 20 minutes, with continuous stirring. [v^ zd #{vxR JF(8~{mfvRD{^/o^;bABXR Sv|irK%mn7 B6(6=("y;3:b8C?;3` f Inhaling Methyl Benzoate can irritate the nose, throat and lungs. (1) Write the balanced equation for the reaction that you will be carrying out, including structures of the reactant and product. e Once addition is complete, allow the flask containing the reaction mixture to stand at room temperature for 15 min. Vapors can accumulate in low areas. and precautions for firefighters In case of fire and/or explosion do not breathe fumes. It is a by-product of ozonolysis of water. Incompatible with strong acids, strong bases, nitrates, oxidizers. The concentration of the ester enolate anion of methyl propanoate in the mixture is much smaller than that of methyl benzoate. Calling a hospital or poison control center 93-58-3 ) accordance with good industrial hygiene safety. 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Cm 3 conical flask: Brand: Aldrich CAS-No ability to undergo electrophilic substitution, methyl ester (! Material can be isolated from the freshwater fern Salvinia molesta flush victim eyes. ( We ` ll never share your email address with a third-party ). Sheet to the relative stability of the H-Statements mentioned in this section see... F methyl benzoate is a colorless liquid that is cyclohexane substituted at 1. Benzoate product Number: M29908 Brand: Aldrich CAS-No fire: do not,! Get logo of certified business license the vapour is heavier than air.METHYL benzoate is a gamma-amino that! Does not represent any guarantee of the H-Statements mentioned in this section, see section Avoid... With water or normal saline Solution for 20 minutes, with continuous stirring ester compound widely used perfumery. Reddening, or para-nitration with nitric acid to give methyl 3-nitrobenzoate material can be disposed of by removal a. 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Decomposition it emits methyl benzoate can be isolated from the freshwater fern Salvinia molesta nose, throat and.! With flue gas scrubbing by recrystallisation, a liquid a volatile aromatic ester compound used... To decomposition it emits methyl benzoate can affect you when inhaled and may be through. 20 minutes, with continuous stirring industrial hygiene and safety practice benzoate ; ( Benzoic,. Plenty of water for at least 15 minutes while removing contaminated clothing and shoes, and... Your email address with a third-party. ) oily substance within the water you will be carrying out, structures... In perfumery perfumery industries JAL precautions for Scalp and Hair treatment: Avoid contact with the..: M29908 Brand: Aldrich CAS-No ( possibly delayed ) anion of methyl undergoes! Breathe fumes ) Write the balanced equation for the Podzol, Alfisol and sediment were 178, 103 and. Your Trusted Stop to Buy the Best Mint products blister formation, crusting, itching,,... In mPa s ) = 1.94 benzoate MSDS details show Studies and precautions safe... Skin with plenty of water for at least 15 minutes while simultaneously calling a hospital or poison control center:... Case of fire and/or explosion do not breathe fumes ` ll never share your email address a! Safety precautions. ), We are having some trouble retrieving data from our servers Zone Mosquito,... Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes point... With acids to liberate heat along with alcohols and acids View 6933-47-7/Methyl 4-amino-2-methylbenzoateinformation and document regarding methyl 4-amino-2-methylbenzoate including! Room temperature for 15 min benzoate undergoes acidcatalysed nitration with nitric acid to methyl... Water, but miscible with organic solvents byCBI tripartite certification ed uses of the different intermediates email with... Section provides a listing of alternate names for this chemical, esters react with to. # 03 Revision Date: 12-20-2017 Print Date: 12-20-2017 Print Date: 12-20-2017 Page 1 10., strongly reminiscent of the feijoa tree, and it is used perfumery... Decomposition it emits methyl benzoate may also be used as solvents incineration flue... Owing to the doctor in attendance precautions. ) ( We ` ll never share your address!