This was found not to be histamine dependent.
The coagulation time of plasma was not affected, indicating that the phenomenon may be mediated by an effect on platelets. Cardiovascular lesions also were largely prevented from developing. ResultsDiscussionReferencesDiscussionGroup DiscussionJoin ResearchGate to find the people and research you need to help your work.The effect of prostaglandin E1 in a concentration of 0.1 gamma/ml on the aggregation and disaggregation of thrombocytes and erythrocytes in vitro was studied. The mode of action of such antigen-antibody complexes depends upon the nature of the antigen, upon the antibody and upon the ratio of the two.RésuméL'effet sur les plaquettes sanguines de lapins, des réactions antigéne-anticorps, est étudié in vivo et in vitro.En ce qui conceme les expériences in vivo, la réaction antigéne-anticorps a été déclenchée par l'injection intrapéntonéale de l'antigéne, à des lapins préalablement sensibilisés. 20 minutes later, the blood was drawn and fractionated according to method 10 of Cohn.For the experiments in vitro, plasma of rabbits sensitized to human gammaglobulin was used as the antibody, and I131-labelled human gammaglobulin as the antigen.These investigations gave the following results:1Following injection of the homologous antigen, antigen-antibody complexes of different composition are found in the circulation of the sensitized animals. Cette action est sous la dépendance des deux constituants du complexe et de leurs rapport mutuels.Schlcßfolgerung und ZustrrnrnerzfassungDie Wirkung von Antigen-Antikörper-Reaktionen auf Thrombocyten wurde in vivo und in vitro am Kaninchen untersucht.
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(4) After testing pyrogenic substances and after provoking the systemic hypersensitivity reaction in passively sensitized animals, an increased susceptibility to the pyrogenic effect of other substances was observed.
Farbechtheit, ‐homogenität, ‐intensität und ‐stabilität verbunden mit einfachem synthetischem Zugang sind die Voraussetzungen für die Anwendung dieses großen, meist planaren aromatischen π‐Systems als Farbmittel. The possible role of local increase in vascular permeability in certain experimental disease states in the localization of circulating complexes is discussed.The fate of three proteins, crystalline hen's egg albumin, crystalline bovine plasma albumin, and human plasma γ-globulin, was traced after intravenous injection into mice. Rat anaphylatoxin was found to cause vascular localization and symptoms of anaphylaxis identical with that brought about by antigen-antibody anaphylaxis. Das Antigen wurde den sensibilisierten Kaninchen intraperitoneal einverleibt, worauf nach 20 Minuten Blutentnahme und Fraktionierung des Plasma nach der Methode 10 von Cohn erfolgte. Prostaglandin E1 failed to cause disaggregation of erythrocytes. This, as in previous studies, suggested an increase in vascular permeability during which large molecules were capable of being trapped by a filtering membrane in the vessel wall. Depletion of platelets, the principal reservoir of vasoactive amines, had a similar though less pronounced effect. If you do not receive an email within 10 minutes, your email address may not be registered, This also was found to be dependent upon the release of histamine. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. The source of the histamine may have been the mast cell as noted in studies employing a direct attack on the mast cells by octylamine.
We use cookies to offer you a better experience, personalize content, tailor advertising, provide social media features, and better understand the use of our services. Sibirien: Bedeutung f ur die Platznahme des Kanskiy Granulit-Komplexes. They are made available as submitted by the authors. The reaction was then released by intraperitoneal injection of the antigen into the sensitized rabbits. Such treatment markedly inhibited the localization of immune complexes in glomeruli, the development of proteinuria, and glomerular endothelial proliferation.
Platelets played apparently little to no role in guinea pigs in the anaphylactic deposition of circulating complexes. It was found that each of the three proteins was present in the nuclei of each cell type enumerated above, often in higher concentration than in the cytoplasm.