A. When animals are used, AAALAC works with institutions and researchers to serve as a bridge between progress and animal well-being. Which Public Health Service (PHS) organization is responsible for monitoring organizational compliance with PHS Policy? Which of the following sets of IACUC members are required by the AWA and/or PHS? Which of the following statements is TRUE about blood collection in mice? D. Carbon dioxide should not be combined with premedication with inhaled anesthetics to euthanize mice. Which Public Health Service (PHS) organization is responsible for monitoring organizational compliance with PHS Policy? D. Written postoperative care records are not necessary, as long as proper care is provided and treatments are administered. AAALAC International is a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. B. C Sterile surgical techniquethe goal of which is to prevent contamination of the surgical siteis required for major and minor survival surgery. ), "Exemptions. Treatments under the program may be declined, but enrollment may not. C If the IACUC decides that any animal activities must be stopped to protect either animals or humans, it is given clear regulatory authority to do so. But like others in the animal welfare arena, AAALAC endorses the use of animals to advance medicine and science when there are no non-animal alternatives, and when it is done in an ethical and humane way. C. Major surgery in which anesthetics and postoperative analgesics are administered. What is NOT a recommendation for postoperative care of mice? Which observation might indicate pain and thus the need for postoperative analgesia? Meet people who A public relations specialist, veterinarian, person who is not a scientist, and person who is not affiliated with the organization. B. D. Postoperative analgesia should be discussed with and approved by a veterinarian. Dose rates (ml/kg) of injectable agents are the same for all common laboratory animal species. Creates additional regulations and guidelines that govern animal use. A change in principal investigator. The Guide for the Care and Use of Agricultural Animals in Agricultural Research and Teaching (the Ag Guide). Contracting with a commercial enterprise to produce custom antibodies requires IACUC approval. One book, The Guide for the Care and Use of Laboratory Animals serves as the basic standard represented by AAALAC accreditation. If a procedure would be painful in a human, one should assume that it would be painful in an animal. A. Along with meeting all applicable local and national regulations, AAALAC accredited institutions must also demonstrate that they are achieving the standards outlined in the Guide for the Care and Use of Laboratory Animals (Guide, NRC 2011); the Guide for the Care and Use of Agricultural Animals in Research and Teaching (Ag Guide, FASS 2010); and the European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes, Council of Europe (ETS 123). A. When the American Plains states were settled, no trees existed for the construction of housing. D. Animal and Plant Health Inspection Service (APHIS), B According to PHS (2015), OLAW "has responsibility for the general administration and coordination of the Policy, provides specific guidance, instruction, and materials to institutions that must comply with the Policy.". Which of the following represents good practice in oral gavage of mice? With great appre ciation to rese archers, IACUC members, veterinarians, EH&S and IACUC specialists, we announce that AAALAC has finalized their review of UCSFs animal care and A. If an organization accepts PHS funds or is registered with the USDA as a research organization, any protocol suspension must be reported by the Institutional Official to OLAW and USDA. D. The selection of an appropriate euthanasia method should address considerations of humaneness to the animal, safety for the staff and onlookers, and experimental needs. B. A. Inoculation of biological toxins into mice and rats D. It is unacceptable to decapitate neonates with scissors, even with IACUC approval. The program started in 1965, when leading veterinarians and researchers organized the American Association for Accreditation of Laboratory Animal Care (AAALAC), as a private, nonprofit organization. B. In 1996, AAALAC changed its name to the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC International). Which of the following is NOT a reason to provide environmental enrichment? B. A. Obtain approval of the animal husbandry staff. one of the actions identified in the report reducing administrative burden for researchers: animal care and use in research in response to the 21st century cures act is to encourage aaalac-accredited institutions to use sections of the aaalac international (aaalac) program description (pd) in applicable parts of the olaw animal welfare assurance Lets start with the sandy beaches, warm water, and fantastic weather. Ambient air is at $25^{\circ} \mathrm{C}$ and $1 \mathrm{~atm}$. B. B According to the AWR (3.81.d. A total number of 15 lines (5 + 4 + 3 + 2 + 1) will be obtained in this Who better to ask than your local auto body shop? The five flows in marketing channels discussed in the text are. For 50 years, the scientific community has activelyand voluntarilyparticipated in AAALAC's accreditation program. C. Institutional Animal Care and Utilization Corps Which of the following is a role of AAALAC International? C. Nobody D Sterile technique is not required for non-survival surgery, but fur clipping and clean instruments are. A mouse with a moderately painful condition may appear and behave normally. AAALAC International promotes the responsible treatment of animals in science through a voluntary accreditation program. Which of the following does not generally represent a good practice to follow when performing infectious disease work in animals? A. Nonaseptic surgical practices are acceptable when it can be shown that mice do not develop postsurgical infections. What is a safe bleed volume for a 20-gram mouse? AAALAC International standards for accreditation are set forth by the Guide for the Care and Use of Laboratory Animals, established by the U.S. National Research Council in 2011. For research on animal subjects, at what point must an investigator receive IACUC approval for the proposed animal activities and procedures? C. Dry ice is an acceptable source of CO2 for euthanasia. Long-term anesthesia is best achieved by repeat dosages of a short-acting injectable anesthetic cocktail. Thermal support is required by USDA regulations. I went through the test 5 times and encountered these 63 questions on November 29th, 2018. Your research must comply with the Guide for the Care and Use of Laboratory Animals if: Your institution receives funds from the National Institutes of Health (NIH). A dedicated surgery suite must be used for which surgery? Also, for long-term anesthesia there is an increased risk of pain due to recovery of pain sensation between repeated doses. Thermal support is an important aspect of postoperative support. B. The shared use of tissues by more than one investigator to minimize animal use. D. Those organizations that accept Public Health Service (PHS) or National Science Foundation (NSF) funding. B. D. Write animal use protocols for investigators. Which statement is true regarding anesthesia in mice? What group determines if a euthanasia method is acceptable for use in a particular species? AAALAC accreditation also promotes scientific validitywhen research involves animals, reliable results depend on healthy animals and superior animal care. Which of the following are NOT allowed by USDA? What is a problem that is often encountered with mice housed on wire mesh flooring? B. Which measure can correct respiratory depression in anesthetized mice? A protocol submitted to the IACUC should C AAALAC International (2017) describes itself as "a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. As AAALAC's accreditation program has grown to encompass many wildlife and agricultural animal research programs, dropping the use of the word "laboratory" in conjunction with AAALAC allows for greater inclusivity. Inspect the animal facilities at the time of each protocol submission If the funds used to contract for custom antibody production are from the PHS, the IACUC should ascertain that the commercial enterprise has a current Animal Welfare Assurance with the PHS. A. Behavioral reasons (such as aggression by C57BL/6 male mice) Federal policies and guidelines require humane treatment of laboratory animals: Which statement best describes the in vivo method of monoclonal antibody production? Office of Laboratory Animal Welfare (OLAW) B Collection of blood by cardiac puncture can result in bleeding into the pericardial sac and tamponade (death), and should only be done terminally. C. The Institutional Official in charge of the research program Weve got your back. C. Applicable federal mandates require the use of aseptic technique for survival surgery in mice. Surgery that penetrates and exposes a body cavity or produces substantial physical impairment is defined as what kind of surgery? Wire mesh floors B. Modify the animal protocol form and keep a copy for their files. D. Mice displaying normal behavior can be assumed to be free of pain and distress. Which of the following statements is/are TRUE regarding preparation of a mouse for surgery? A As a prey species, rodents are genetically programmed to mask signs of pain or distress. Changes in principal investigator, objectives, species, or type of surgery can never be approved by this method. A. In addition, more than 60 prestigious scientific, educational and other professional organizations are members of AAALAC International. The Council conducts on-site visits and extensive evaluations, and provides ongoing advice to help organizations achieve and maintain accreditation. C. Sterile technique is required for non-survival surgery even though infections are not a concern. C. The veterinarian cannot exempt an animal, even for medical reasons. C. Dogs and cats The overlap between groups has ______ in americas residential neighborhoods and workplaces. The researchers and regulatory agencies only C. The IACUC has regulatory authority to stop any animal activities to protect either animals or people. A change from non-survival to survival surgery Which of the following is a role of Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International? Compared to adults, neonates are much more susceptible to low oxygen levels, and quickly succumb to death by carbon dioxide inhalation. Write an expression using boolean variables a and b that evaluates to true when only one of a and b is true, and that is false if a and b are both false or both true. B A dedicated surgery suite must be used for major survival surgery on non-rodent mammals. B. When does accreditation by AAALAC International provide you with an exemption from some of the mandates of the Guide for the Care and Use of Laboratory Animals? After any preliminary work with the animals that is needed to finalize the design of the procedures, but before the formal study begins. D. Contact with wild mice in field studies is a risk for exposure to zoonotic diseases. However, agricultural animals used in biomedical research may need to be housed according to the Guide while on study. Before any use of the animals for the project begins. Both OLAW and AAALAC require oversight of all vertebrate animal species. A simple rule to prevent excess blood collection in an animal is to collect no more than what percentage of body weight as blood at one time? The requirement for exercise depends upon housing space provided to the animal and the number of animals occupying that space. The balloon material has a mass of $60 \mathrm{~g} / \mathrm{m}^2$. It requires annual reports from its accredited facilities C. It conducts site visits every 3 years D. It is a government - sponsored agency 16. A microchip is injected subcutaneously with a hypodermic needle. Non-USDA regulated species are never required to be placed in a pain/distress category. D. The Office of Laboratory Animal Welfare (OLAW). Institutional Animal Control and Use Committee Some use accreditation as a symbol of qualityit shows that an institution is serious about setting, achieving and maintaining high standards for animal research programs. IACUCs are not mandated to write the basic science portions of grant applications or animal use protocols for investigators. A. C The NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules deal only with recombinant infectious agents. Adoption in other countries and by agricultural and wildlife programs. B. B. If an organization accepts PHS funds or is registered with the USDA as a research organization, any protocol suspension does not have to be reported by the Institutional Official to OLAW and USDA. Which of the following is TRUE regarding the Animal Welfare Regulations and duplication of experiments? C. Mice lose body heat rapidly under anesthesia. B. Postoperative analgesia is not generally needed in rodents. Lethal dose experiments in which animals are allowed to die without intervention. Animal forms must be rewritten to solicit continued IACUC approval. Which of the statements concerning blood collection in mice and rats is TRUE? D. Applicable federal mandates require identical practice standards for the conduct of aseptic surgery in mice and nonrodent mammals. Which of the following institutions must follow PHS guidelines for animal research? Currently nearly 900 companies, universities, hospitals, government agencies and other research institutions in 40+ countries have earned AAALAC accreditation, demonstrating their commitment to responsible animal care and use. D. Animals should only be used in human clinical areas during weekday work hours. What does "IACUC" stand for? B. Pre-operative planning is very important. Unnecessary duplication of animal experiments is not allowed. A. Nonverbal communication is defined as how people communicate with each other without talking or writing. Assist with writing the basic science portions of a grant application Collecting tail snips from adult rodents for genotyping under local or general anesthesia. You can help Wikipedia by expanding it. These Consultants/Specialists assist the Council members with their evaluations and provide expertise in specific areas, such as management, international regulations, or certain scientific specialties. B. Which of the following is not a good justification for housing animals individually? A. If so, then you should check out the best BB creams on the market. D The federally mandated search for alternatives helps to fulfill the requirement set forth in the AWA policies to consider alternatives to procedures that may cause more than momentary pain or distress. The USDA requires documentation of all postoperative care and retention of records for one year after the death of the animal. B. The IP injection site is on the animal's right side, close to the midline, in a caudal quadrant of the abdomen. If the investigator believes the event is due to misuse, mistreatment, or noncompliance, the details of the incident should be reported to the IACUC (or use another reporting method recommended by their organization), so that the incident can be reviewed and investigated (if warranted). Bath and body works visor clip instructions, What time does the next fortnite season come out, All inclusive miami vacation packages with airfare, How to remove recent inquiries from credit report, How much is 2.5 liters of water in gallons. Anesthesia of the mouse can increase esophageal trauma caused by the gavage. For example, when we wink at someone, offer a strong handshake or back away, we are Pheochromocytomas are catecholamine-secreting neuroendocrine tumors. ", A simple rule to prevent excess blood collection in an animal is to collect no more than what percentage of body weight as blood at one time? a. The Association for Assessment and Accreditation of Laboratory Animal Care, International (AAALAC) is a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. A. The Association for Assessment and Accreditation of Laboratory Animal Care International, or AAALAC, is a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. $$ C. Sponsors a voluntary accreditation program for animal care and use programs. In Section 3.4, new literature is explored and the assessment of impacts and projected risks is updated for a large number of natural and human systems. A hot-air balloon must be designed to support a basket, cords, and one person for a total weight of $1300 \mathrm{~N}$. The Public Health Service (OLAW) B. Inoculation of nonrecombinant infectious agents into animals An organization that receives PHS funds must report any suspension to OLAW; however, OLAW is not authorized to overturn IACUC suspensions. D Organizations receiving funds from PHS agencies are required to comply with the PHS Policy. B. Major survival surgery on rodents Which of the following statements about the postoperative period is FALSE? C. Zoonotic diseases are very common in specific-pathogen-free laboratory mice. A. A. C. Survival A. Which of the following statements about caging for mice reflect the information that is in the Guide for the Care and Use of Laboratory Animals? D. If an animal undergoes non-survival surgery, the fur around the surgical site should be clipped and clean instruments should be used. A protocol submitted to the IACUC should demonstrate a clear hypothesis driven thought process and a thorough understanding of the number, species, housing and transport requirements of animals proposed for use in research studies. ${ }_{36}^{87} \mathrm{Kr} \longrightarrow-0 \beta+$. B. Non-survival They are methods that are acceptable as a follow-up procedure for ensuring death. The IACUC is also not mandated to inspect animal facilities at the time of protocol submissions but is mandated to inspect animal facilities on a semiannual basis. What is a primary mission of the Animal Welfare Information Center (AWIC), a part of USDA? Locked bedroom doors are a common sight in many homes. A public relations specialist is not part of this mandate. C Changes that may, or may have, a negative effect on animal welfare (including changes in anesthetic or the number of procedures) and changes in principal investigator are considered significant that require IACUC review and approval. Members of the Council are chosen to serve based on their extensive experience in the fields of veterinary medicine, laboratory animal science or animal research, and their commitment to humane animal care and use. A Category E of the USDA report form applies to " animals upon which teaching, experiments, research, surgery or tests were conducted involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic, analgesic, or tranquilizing drugs would have adversely affected the procedures, results, or interpretation of the teaching, research, experiments, surgery, or tests.". The Guide to Proper Procedures in Research Facilities Non-vertebrates, laboratory mice, and laboratory rats. C. Solid bottom cages with contact bedding Which of the following protocol changes require IACUC approval? What is the maximum number of emission lines possible for a hydrogen atom in the n 4 state? A Good practice when performing infectious disease work in animals includes working with hand covers; obtaining an antimicrobial sensitivity panel for the infectious agent; anesthetizing or sedating animals to reduce chances of accidental human needle sticks; and completing work in pairs. A. where $x$ is in meters and $t$ is in seconds. C. The use of newer surgical techniques that result in less tissue trauma. D. Observation studies of normal primate behavior. Using appropriate personal protective equipment can reduce the risk of allergies to mouse urine and pelt proteins. Association for Assessment and Accreditation of Laboratory Animal Care International, Learn how and when to remove these template messages, "Association for Assessment and Accreditation of Laboratory Animal Care International", Learn how and when to remove this template message, Physicians Committee for Responsible Medicine, American Association for Laboratory Animal Science, https://en.wikipedia.org/w/index.php?title=Association_for_Assessment_and_Accreditation_of_Laboratory_Animal_Care_International&oldid=1054465657, Animal welfare organizations based in the United States, Articles lacking reliable references from May 2008, Articles needing additional references from October 2021, All articles needing additional references, Articles with multiple maintenance issues, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 10 November 2021, at 05:42. Once a report of mistreatment, misuse, or noncompliance is received, the AWR and PHS Policy require the IACUC to review and investigate the allegations (if warranted).
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