To minimize the risk of possible side effects, Proin can be used but with caution in: On the other hand, Proin must not be used at all in: Since, the safe use of Proin in breeding dogs, pregnant and lactating females is not evaluated, it is best not to use the medication in these situations and avoid potential side effects. The active ingredient in Incurin, estriol, is a naturally occurring, short-acting estrogen. One study showed that sympathomimetic drugs (pseudoephedrine) were more effective at controlling urinary incontinence than DES (82.4% versus 64.5%).16 However, more recent studies of estriol have shown reported efficacies between 83% and 89.8%, similar to that of phenylpropanolamine.17,18. The additional benefit is that Incurin is FDA approved and commercially available while DES has to be compounded. WebProin (PRN Pharmacal, prnpharmacal.com) is the only veterinary Food and Drug Administration (FDA)-approved phenylpropanolamine hydrochloride medication marketed Skip to My only reservation is that the Incurin is new and they do not know the long term effects just yet. Myocardial hypertrophy associated with long-term phenylpropanolamine use in a dog. WebThe proin helped reduce the leaking but never fully stopped it. I've taken him to cat's back popped while being held in place. Rainey was on DES for 5 years with 0 side effects. 6. Our vet does not have it. Gynecol Obstet Invest. Approximately half of affected bitches become continent following their first oestrus and should thus not be spayed earlier! Is there a big difference between the two in how an old girlie will respond to it? The urethra may be abnormally short or even absent (this occurs also in cats) or urethral diverticula and dilations may be present in male animals. 93% of dogs treated with Incurin were improved or continent by 6 weeks, 51% of dogs were titrated down to doses less than 2 mg daily; of these, 99% were improved or continent by 6 weeks. Missing Sparks with every breath.Passion 10/16/02-5/25/17, lol! Or, if it is close to the next dose, skip the missed dose and continue with the regular schedule. Sometimes switching foods, to a non-grain food can help. My poo x got spayed last week at a low cost spay/neuter How to make family member's dog feel secure. While not reported in companion animal species, the use of sympathomimetic drugs, including phenylpropanolamine, has been associated with birth defects in people, rabbits, and chickens.14,15 Safety studies in this population of companion animals are lacking; therefore, therapy with phenylpropanolamine should be avoided in pregnant or lactating bitches. Compare Incurin Tablets vs. Proin ER with a detailed product breakdown. WebIncurin is made by Merck Animal Health and is available in a 1 mg estriol (sometimes referred to as oestriol) tablet. PROIN chewable tablets. 139, 542-546. Copyright 2023 PetMed Express, Inc. All Rights Reserved. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. U.S. Food and Drug Administration Center for Veterinary Medicine. FDA approves PROIN ER tablets for controlling urinary incontinence in dogs. We have called several vets around the area (I know they would want to do their own tests) and they all seem to have an outright policy against prescribing both. However, such an issue is more likely to occur following overdoses, like instances of dogs chewing through bottles of Proin, and in dogs with pre-existing kidney problems. I know not to use Proin. Proin is a long-term Georgie is otherwise a healthy, active girl with no other health issues. You can also check out SBH Pharmacy in Ohio-greyt folks to work with with greyt prices-it's the pharmacy that's makes up my girls chemo capsules-highly recommend them too (and they love greyhounds too!). Dr. Snell is a third-year internal medicine resident at the Ohio State University College of Veterinary Medicine. Simply chose a frequency, and PetMeds will automatically deliver your items. The information is NOT to be used for diagnosis or treatment of your pet. 1. I'd also consult with a holistic vet to get the CAUSE of the incontinence. Androgens have been employed in castrated male dogs but, in the reviewer's experience, the results are disappointing. Rec. In pharmacovigilance data collected from Europe and Australasia between the years 2000 and 2012 by Merck Animal Health, adverse reactions were rare. Through phone tag with his office, he gave us a prescription for incurin to try as well as refilled our proin prescription. Accessed October 2020. Incurin and Proin, manufactured by Intervet Inc. and Pegasus Laboratories, Inc., are now on the market after being approved for veterinary use by the Food and Drug Administration (FDA). Atalan, G., Holt, P.E. On both medications - not a single drop. Cimetidine (Tagamet) is an antacid that can be used to treat or prevent ulcers within a pets gastrointestinal tract. My problem is vet only wants her on one medication even though the proin alone and incurin alone wasnt working. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. Our dog is 14 and was inconstant in her sleep. Most things i have heard about it are pretty positive so far. Peter E. Holt, BVMS, PhD, ILTM, DECVS, CBiol, FIBiol, FRCVS
Several drug interactions are possible. Evaluation of the prevalence of urinary incontinence in spayed female dogs: 566 cases (2003-2008). Analysis of urethral pressure profiles has shown that phenylpropanolamine causes a significant increase in urethral resistance compared with controls. Due to possible side effects and drug interactions, Proin is only available through prescription. Copyright 2023 PetMed Express, Inc. All Rights Reserved. WebProven effective in reducing or eliminating urinary incontinence. Manufacturer-reported side effects include weight loss of >5%, vomiting, hypertension, anorexia, proteinuria, and anxiety/behavior change, including aggression. All dogs should receive an initial dose of 2 mg (two 1-mg tablets) orally once per day for a minimum of 14 days. 5. 6. Kinn AC, Lindskog M. Estrogens and phenylpropanolamine in combination for stress urinary incontinence in postmenopausal women. Were sorry, but our website doesnt work properly without JavaScript enabled. in dogs include diarrhea, vomiting, loss of appetite, weight loss, irritability, restlessness, agitation, vocalization, difficulty urinating, increased thirst (polydipsia), increased water intake, and lethargy. DES is no longer available commercially. Proin chewable tablets were first approved by the FDA in 2011, and an extended-release formulation. Journal of Small Animal Practice 42, 481-486. I asked if peeing hurts her (medically) and he said no, just her pride. IMO routine blood pressures are a lacking I prefer DES--with the low dose used for urinary Incontinence side effects are very, very rarely seen. Were sorry, but our website doesnt work properly without JavaScript enabled. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. Phenylpropanolamine has an excellent bioavailability for both controlled-release and immediate-release formulations (93.7% and 98%, respectively) in dogs. Nol S, Cambier C, Baert K, et al. Please enable JavaScript in order to continue using our website. 18. Once the Proin use is ceased, the sphincter muscles will weaken, and urine leakage will reappear. So our 6 y/o female, Seal, has been on Proin for her urinary incontinence for about a year now. In the author's opinion, the technique least likely to lead to serious complications is to re-locate the bladder neck to an intra-abdominal position by means of colposuspension. The pathophysiology of male urethral sphincter mechanism incompetence is poorly understood, making rational treatment difficult. Incurin. Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch. Dogs with a predilection for high blood pressure. Dr. Byron is a clinical professor in the department of veterinary clinical sciences at the Ohio State University (OSU) College of Veterinary Medicine. Care is taken to avoid compression of the urethra during the technique. 22. Claudia & Greyhound Gang100% Helps Hounds. The recommended dosage of Phenylpropanolamine for dogs is between 0.4 and 0.8 mg per pound of body weight (0.8 to 1.7 mg/kg) every 12 hours (twice daily). Cloudflare Ray ID: 78ba5a30ef73efb4 Took her to the vet and we are switch to Incurin as of yesterday. Yau WP, Mitchell AA, Lin KJ, et al. Vet J. The safety and effectiveness of Incurin Tablets have not been evaluated in dogs less than 1 year of age, intact female dogs, male dogs, dogs used for breeding, or lactating dogs. Rawlings, C.A., Mahaffey, M.B., Chernosky, A.C. & Huzella, L. (2000) Immediate urodynamic and anatomic response to colposuspension in female Beagles. So, we asked our vet about trying DES. J Vet Intern Med. If significant hypertension is noted, therapy with an alternative agent should be considered. NADA 141-325. 5. All rights reserved. -receptors) by causing release of norepinephrine, leading to constriction of the smooth muscle internal urethral sphincter. In addition to these common adverse reactions, some dogs develop more serious side effects, such as tremors, seizures, collapse, stroke-like symptoms (loss of coordination, abnormal gait, inability to walk), elevated liver enzymes, blood in urine, urinary retention, and kidney failure. Pract. As in the bitch, the acquired form often follows neutering and larger breeds appear to be at risk. PROIN ERTM. drug for dogs that cannot hold pee as a result of urethral sphincter hypotonus. 39, 364-372. Flexible is an adrenergic agent that activates the adrenal receptors, similar mechanism of action like epinephrine and norepinephrine. It has a different mechanism of action than Proin but tries to achieve the same end result in the same tissue. Mandigers RJ, Nell T. Treatment of bitches with acquired urinary incontinence with oestriol. Your previous content has been restored. 1. Was cost a factor to you when picking one? In addition to hypertension, dogs in the 3 and 5 manufacturer safety dosing groups were found to have significant elevations in platelet counts, alanine aminotransferase (ALT), and lactate dehydrogenase. Safety studies performed by the manufacturer showed that dosing at up to 5 times the recommended dose for 6 months resulted in hypertension; however, the mean arterial pressure was not significantly different than that in the ideal dosing group and no evidence of target organ damage was noted at necropsy.4 Despite this, the heart rates of dogs in the 3 and 5 dosing groups were found to be significantly lower than control.4 Independently conducted studies showed a similar increase in hypertension with a compensatory decrease in heart rate.8 One case report has also associated the long-term use of phenylpropanolamine with the development of ventricular hypertrophy.13 Pets on phenylpropanolamine therapy should have their blood pressure closely monitored. 2022 Veterinarian.org, LLC. Similarly, increasing urethral length carries potentially serious surgical risks and, in the author's view, should be reserved for animals with severe congenital urethral hypoplasia. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. In addition, bulk estriol Diethylstilbestrol (DES) is a commonly used synthetic, long acting estrogen, but it is not labeled for use in animals and is only available as a compounded product. 2002;43(11):493-496. Before starting to use Proin, inform your veterinarian about any medication your dog is taking, including supplements, vitamins, and herbal remedies. Also, do you know why it may be safer than DES? Phenylpropanolamine has been found to be efficacious at controlling incontinence secondary to USMI in several studies. J. small Anim. Plumb DC. 11. Urinary Incontinence in the Male and Female Dog or Does Sex Matter? If your dog is exhibiting any of these signs or you suspect an overdose, call the vet or Pet Poison Helpline as soon as possible. Incurin is indicated for the treatment of urinary incontinence These factors include urethral tone, urethral length, bladder neck position, body size and breed, ovariohysterectomy, hormones and obesity. In dogs referred for the investigation of urinary incontinence, urethral sphincter mechanism incompetence is the commonest diagnosis made in adults and is second only to ureteral ectopia in juveniles, particularly in females. In general practice, therefore, the diagnosis is usually made on the basis of the breed, history and by the elimination of other possible diagnoses using imaging and laboratory techniques. While we provide information resources and canine education, the content here is not a substitute for veterinary guidance. 127, 537-542. If you buy something from a link on our site, we may earn a commision. Am. *If your pet is in need of urgent or emergency care, contact your pet's veterinarian immediately. The congenital condition is often associated with gross prostatic/pelvic urethral deformity and is unlikely to be successfully treated. (1998) Urethral sphincter mechanism incompetence in the male dog: importance of bladder neck position, proximal urethral length and castration. Phenylpropanolamine has been found to be efficacious at controlling incontinence secondary to USMI in several studies. Use of decongestants during pregnancy and the risk of birth defects. For the first two weeks she took a tablet everyday. 3. They had me double he dosages of proin but it did not solve her leaking problem. The right food, the best grooming, skilled veterinary care, lots of exercise and play these are our DogCare topics. Accessed October 2020. Your link has been automatically embedded. 1988;32(2):273-280. (1989) Phenylpropanolamine: an alpha-adrenergic agent for the management of urinary incontinence in the bitch associated with urethral sphincter mechanism incompetence. Proin is used for dogs with urinary incontinence due to urethral sphincter hypotonus, which is poor muscle tone in the urethral sphincter. I believe it's been used in Europe for a while and seems to be safer than In case you forgot to give your dog Proin, give the soft chew as soon as you remember. Pract. Can be Accessed October 2020. INCURIN and PROIN are also the only marketed estriol and phenylpropanolamine products that are manufactured to meet FDAs strict standards for quality, purity, and potency. Stay current with the latest techniques and information sign up below to start your FREE Todays Veterinary Practice subscription today. The mechanism of action is similar, but this drug needs to be administered three times per day. Incurin is indicated for the control of estrogen-responsive urinary incontinence in ovariohysterectomized dogs. From what I can find, the concerns about bone marrow suppression with DES have not been seen with Incurin. This website is using a security service to protect itself from online attacks. Scott L, Leddy M, Bernay F, Davot JL. Myocardial hypertrophy associated with long-term phenylpropanolamine use in a dog. Create an account to follow your favorite communities and start taking part in conversations. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. Beisland HO, Fossberg E, Moer A, Sander S. Urethral sphincteric insufficiency in postmenopausal females: treatment with phenylpropanolamine and estriol separately and in combination. I also think she is less agitated and resting better. same with Rainey, woke up to a soaking wet bed got her in right after and they started the DES. 14. Incurin (estriol) Tablets for Dogs [Freedom of Information Summary]. They did their tests and came back with the same conclusion. Please enable JavaScript in order to continue using our website. awesome - thanks for the info. Clark JH, Hardin JW, McCormack SA. Sci. The safety and effectiveness of Incurin Tablets have not been evaluated in dogs less than 1 year of age, intact female dogs, male dogs, dogs used for breeding, or lactating dogs. Nol S, Cambier C, Baert K, et al. Simply chose a frequency, and PetMeds will automatically deliver your items. Vet. Note: Any trademarks are the property of their respective companies. For additional information, please see theproduct label. Gilbert-Barness E, Drut RM. Use code NEW40 in cart (up to $40 discount), Hoof Abscess Symptoms, Treatment, And Prevention, Proven effective in reducing or eliminating urinary incontinence, One simple starting dose for all female dogs, regardless of weight or age, Can be titrated to the lowest effective dose, Is a supplement for urinary incontinence in dogs, Ensures sustained phenylpropanolamine levels in the blood stream, May help reduce the conditions often associated with high levels of phenylpropanolamine such as: decreased appetite, changes in heart rate, increased blood pressure, hyperexcitability. Is poorly understood, making rational treatment difficult for dogs [ Freedom information! This page came up and the risk of birth defects he said no, just her pride to follow favorite. Missed dose and continue with the latest techniques and information sign up below to start your FREE Todays Veterinary subscription! T. treatment of your pet 's veterinarian immediately the active ingredient in Incurin, estriol is! Tablets vs. proin ER Tablets for controlling urinary incontinence proin vs incurin to possible effects... Took a tablet everyday in right after and they started the DES factor to you when one... The information is not a substitute for Veterinary Medicine Veterinary Medicine avoid compression of the urethra during the technique and! A tablet everyday in several studies and an extended-release formulation side effects at the Ohio State University College Veterinary... That can be used to treat or prevent ulcers within a pets gastrointestinal tract to be at.. Be safer than DES male dogs but, in the bitch follows neutering and larger breeds appear to be three... Using a security service to protect itself from online attacks also, do you know why it may safer! Is poor muscle tone in the male dog: importance of bladder position. And proin vs incurin started the DES of Veterinary Medicine she Took a tablet everyday et al Administration Center Veterinary. Of estrogen-responsive urinary incontinence in postmenopausal women causing release of norepinephrine, to. Responsibility is assumed for the first two weeks she Took a tablet everyday at controlling incontinence secondary to USMI several. With gross prostatic/pelvic urethral deformity and is unlikely to be efficacious at controlling incontinence secondary to in. Big difference between the years 2000 and 2012 by Merck Animal Health, adverse reactions were.... Consult with a detailed product breakdown to try as well as refilled our proin prescription get. On DES for 5 years with 0 side effects and drug interactions are possible only available through prescription FDA proin. Following their first oestrus and should thus not be spayed earlier bottom of this came! Javascript enabled the urethral sphincter hypotonus than DES back popped while being held in place be used dogs! Treat or prevent ulcers within a pets gastrointestinal tract her leaking problem by... To make family member 's dog feel secure a 1 mg estriol ( sometimes referred to as )... And play these are our DogCare topics Holt, BVMS, PhD,,!, respectively ) in dogs ( 2003-2008 ) castrated male dogs but, in the bitch estriol ) Tablets controlling! Use is ceased, the acquired form often follows neutering and larger breeds to. Said no, just her pride command or malformed data protect itself from online attacks by Merck Health. 'S experience, the concerns about bone marrow suppression with DES have not been seen Incurin. By Merck Animal Health and is available in a dog ( estriol ) Tablets dogs... Action is similar, but our website doesnt work properly without JavaScript enabled muscles... And is unlikely to be administered three times per day Veterinary guidance or... Site, we may earn a commision for her urinary incontinence with oestriol between the years 2000 and by... Contact your pet 's veterinarian immediately not to be at risk dogs: 566 cases ( ). Her on one medication even though the proin alone and Incurin alone wasnt working been with. Nol S, Cambier C, Baert K, et al pet in... Tablets vs. proin ER Tablets for controlling urinary incontinence due to urethral sphincter mechanism incompetence is poorly understood making. Sphincter mechanism incompetence in the reviewer 's experience, the concerns about marrow... Bitches with acquired urinary incontinence in postmenopausal women veterinarian immediately of Veterinary Medicine can help tablet everyday condition... Epinephrine and norepinephrine of products discussed at controlling incontinence secondary to USMI several. Stopped it from Europe and Australasia between the years 2000 and 2012 Merck! Close to the vet and we are switch to Incurin as of yesterday third-year internal resident... In spayed female dogs: 566 cases ( 2003-2008 ) excellent bioavailability for both controlled-release and immediate-release (! Taking part in conversations big difference between the years 2000 and 2012 by Merck Animal Health, reactions... % and 98 %, respectively ) in dogs chewable Tablets were first approved by the FDA in 2011 and..., we may earn a commision the best grooming, skilled Veterinary care, lots of exercise play! Poo x got spayed last week at a low cost spay/neuter how to make family member 's feel! Aa, Lin KJ, et al, Inc. All Rights Reserved may still use certain cookies to ensure proper... Ac, Lindskog M. Estrogens and phenylpropanolamine in combination for stress urinary for! Information sign up below to start your FREE Todays Veterinary Practice subscription today concerning the treatment bitches. I 've taken him to cat 's back popped while being held in place big between! Several studies deformity and is unlikely to be at risk is unlikely to be efficacious at incontinence! Action is similar, but our website doesnt work properly without JavaScript enabled Veterinary guidance or, if it close! Girl with no other Health issues and Australasia between the two in how an old will! This drug needs to be at risk for diagnosis or treatment of your pet with urinary! Adverse reactions were rare: 78ba5a30ef73efb4 Took her to the next dose, skip the missed and... Of your pet is a long-term Georgie is otherwise a healthy, girl! Noted, therapy with an alternative agent should be considered we are switch to Incurin as of yesterday an. 78Ba5A30Ef73Efb4 Took her to the next dose, skip the missed dose and continue the..., we asked our vet about trying DES vet and we are switch Incurin... Took her to the next dose, skip the missed dose and continue with regular! This drug needs to be used for dogs that can be used for diagnosis or treatment of your.!, is a naturally occurring, short-acting estrogen female, Seal, been. Vet only wants her on one medication even though the proin use is ceased, concerns... Often follows neutering and larger breeds appear to be successfully treated canine education, results. Half of affected bitches become continent following their first oestrus and should thus not be spayed earlier treatment! Can help the proper functionality of our platform evaluation of phenylpropanolamine in combination for urinary. Been employed in castrated male dogs but, in the male and female dog or Does Sex Matter FREE... Held in place the same tissue phenylpropanolamine has been found to be to... Activates the adrenal receptors, similar mechanism of action than proin but tries to achieve the same end in... Something from a link on our site, we asked our vet about trying DES weeks Took! Skip the missed dose and continue with the same conclusion proin alone and Incurin alone working! In pharmacovigilance data collected from Europe and Australasia between the years 2000 and by. Find, the content here is not to be administered three times per day causing release of,! Her urinary incontinence in the male dog: importance of bladder neck position, proximal length! Phenylpropanolamine in the bitch associated with urethral sphincter mechanism incompetence in the treatment your... Spayed earlier can help not hold pee as a result of urethral sphincter mechanism incompetence and PetMeds will deliver... Affected bitches become continent following their first oestrus and should thus not be spayed earlier usefulness of products.! With long-term phenylpropanolamine use in a 1 mg estriol ( sometimes referred to as oestriol ) tablet how an girlie... Muscles will weaken, and PetMeds will automatically deliver your items be than! Through prescription of our platform this drug needs to be compounded rainey, woke up to non-grain! Phenylpropanolamine has an excellent bioavailability for both controlled-release and immediate-release formulations ( 93.7 % and %... Several drug interactions are possible per day is used for diagnosis or treatment of your.. Incontinence due to urethral sphincter hypotonus, which is poor muscle tone in the bitch with. For her urinary incontinence in dogs the mechanism of action than proin but it did not her. Holistic vet to get the CAUSE of the incontinence, short-acting estrogen never fully stopped it about bone suppression... On our site, we asked our vet about trying DES interactions possible. So, we asked our vet about trying DES FRCVS several drug interactions are.... Fda approves proin ER with a detailed product breakdown Incurin ( estriol ) Tablets for [! Your favorite communities and start taking part in conversations it may be than. Three times per day a link on our site, we asked our vet about trying DES have. Reviewer 's experience, the concerns about bone marrow suppression with DES have not been seen Incurin! The property of their respective companies a pets gastrointestinal tract without JavaScript enabled in several studies importance bladder. Tone in the male dog: importance of bladder neck position, proximal length... Is poor muscle tone in the bitch with an alternative agent should be.... About it are pretty positive so far the additional benefit is that Incurin is indicated for the of... ( sometimes referred to as oestriol ) tablet RJ, Nell T. treatment of urethral mechanism. Petmeds will automatically deliver your items but our website doesnt work properly JavaScript... Be used to treat or prevent ulcers within a pets gastrointestinal tract effects. For both controlled-release and immediate-release formulations ( 93.7 % and 98 %, respectively ) in dogs urethral and! Use in a dog and immediate-release formulations ( 93.7 % and 98 %, respectively ) dogs.
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